Gene Therapy Progress and Prospects: Gene therapy for diabetes mellitus

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Gene therapy for diabetes mellitus.

1. This review describes experimental approaches to test the feasibility of using gene therapy to administer insulin to type 1 and type 2 diabetic patients. Two approaches, i.e. ex vivo and in vivo transfer of the insulin gene, are described. 2. Substantial progress has been made in recent years in engineering glucose-responsive beta-cell lines that have been genetically engineered to prolifera...

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Objective(s): Diabetes mellitus (DM) is a major worldwide public health challenge, for which gene therapy offers a potential therapeutic approach. To date, no systematic review or meta-analysis has been published in this area, so we examined all relevant published studies on rodents to elucidate the overall effects of gene therapy on bodyweight, intraperitoneal glucose...

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ژورنال

عنوان ژورنال: Gene Therapy

سال: 2004

ISSN: 0969-7128,1476-5462

DOI: 10.1038/sj.gt.3302412